The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication

Host-adaptive strategies, such as the E627K substitution in the PB2 protein, are critical for replication of avian influenza A viruses in mammalian hosts. Here we show that mutation PB2-K526R is present in some human H7N9 influenza isolates, in nearly 80% of H5N1 human isolates from Indonesia and, i...

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Publicat a:Nat Commun
Autors principals: Song, Wenjun, Wang, Pui, Mok, Bobo Wing-Yee, Lau, Siu-Ying, Huang, Xiaofeng, Wu, Wai-Lan, Zheng, Min, Wen, Xi, Yang, Shigui, Chen, Yu, Li, Lanjuan, Yuen, Kwok-Yung, Chen, Honglin
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263149/
https://ncbi.nlm.nih.gov/pubmed/25409547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6509
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