Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes vesicles containing microRNAs (miRNAs) and Y RNAs as well as a nematode Argonaute protein. These vesicles are of intestinal ori...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Buck, Amy H., Coakley, Gillian, Simbari, Fabio, McSorley, Henry J., Quintana, Juan F., Le Bihan, Thierry, Kumar, Sujai, Abreu-Goodger, Cei, Lear, Marissa, Harcus, Yvonne, Ceroni, Alessandro, Babayan, Simon A., Blaxter, Mark, Ivens, Alasdair, Maizels, Rick M.
Format: Artigo
Langue:Inglês
Publié: Nature Pub. Group 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263141/
https://ncbi.nlm.nih.gov/pubmed/25421927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6488
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