Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity

In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that the gastrointestinal nematode Heligmosomoides polygyrus, which infects mice, secretes vesicles containing microRNAs (miRNAs) and Y RNAs as well as a nematode Argonaute protein. These vesicles are of intestinal ori...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Buck, Amy H., Coakley, Gillian, Simbari, Fabio, McSorley, Henry J., Quintana, Juan F., Le Bihan, Thierry, Kumar, Sujai, Abreu-Goodger, Cei, Lear, Marissa, Harcus, Yvonne, Ceroni, Alessandro, Babayan, Simon A., Blaxter, Mark, Ivens, Alasdair, Maizels, Rick M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Pub. Group 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263141/
https://ncbi.nlm.nih.gov/pubmed/25421927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6488
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