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A method for inverse bifurcation of biochemical switches: inferring parameters from dose response curves

BACKGROUND: Within cells, stimuli are transduced into cell responses by complex networks of biochemical reactions. In many cell decision processes the underlying networks behave as bistable switches, converting graded stimuli or inputs into all or none cell responses. Observing how systems respond t...

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Pubblicato in:BMC Syst Biol
Autori principali: Otero-Muras, Irene, Yordanov, Pencho, Stelling, Joerg
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263113/
https://ncbi.nlm.nih.gov/pubmed/25409687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-014-0114-2
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