Oocyte-specific inactivation of Omcg1 leads to DNA damage and c-Abl/TAp63-dependent oocyte death associated with dramatic remodeling of ovarian somatic cells

Aberrant loss of oocytes following cancer treatments or genetic mutations leads to premature ovarian insufficiency (POI) associated with endocrine-related disorders in 1% of women. Therefore, understanding the mechanisms governing oocyte death is crucial for the preservation of female fertility. Her...

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Publicat a:Cell Death Differ
Autors principals: Vandormael-Pournin, S, Guigon, C J, Ishaq, M, Coudouel, N, Avé, P, Huerre, M, Magre, S, Cohen-Tannoudji, J, Cohen-Tannoudji, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262775/
https://ncbi.nlm.nih.gov/pubmed/25168238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.122
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