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Lethality of Sortase Depletion in Actinomyces oris Caused by Excessive Membrane Accumulation of a Surface Glycoprotein

Sortase, a cysteine-transpeptidase conserved in Gram-positive bacteria, anchors on the cell wall many surface proteins that facilitate bacterial pathogenesis and fitness. Genetic disruption of the housekeeping sortase in several Gram-positive pathogens reported thus far attenuates virulence, but not...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Microbiol
Hauptverfasser: Wu, Chenggang, Huang, I-Hsiu, Chang, Chungyu, Reardon-Robinson, Melissa Elizabeth, Das, Asis, Ton-That, Hung
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262642/
https://ncbi.nlm.nih.gov/pubmed/25230351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12780
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