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Importance of Tryptophan in Transforming an Amphipathic Peptide into a Pseudomonas aeruginosa-Targeted Antimicrobial Peptide

Here, we found that simple substitution of amino acids in the middle position of the hydrophobic face of an amphipathic peptide RI16 with tryptophan (T9W) considerably transformed into an antimicrobial peptide specifically targeting Pseudomonas aeruginosa. Minimal inhibitory concentration (MIC) resu...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Zhu, Xin, Ma, Zhi, Wang, Jiajun, Chou, Shuli, Shan, Anshan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262413/
https://ncbi.nlm.nih.gov/pubmed/25494332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114605
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