AMPA Receptor antagonist NBQX attenuates later-life epileptic seizures and autistic-like social deficits following neonatal seizures

PURPOSE: To determine whether AMPA receptor (AMPAR) antagonist NBQX can prevent early mTOR pathway activation and long-term sequelae following neonatal seizures in rats, including later-life spontaneous recurrent seizures, CA3 mossy fiber sprouting, and autistic-like social deficits. METHODS: Long-E...

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Detalhes bibliográficos
Publicado no:Epilepsia
Main Authors: Lippman-Bell, Jocelyn J., Rakhade, Sanjay N., Klein, Peter M., Obeid, Makram, Jackson, Michele C., Joseph, Annelise, Jensen, Frances E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262152/
https://ncbi.nlm.nih.gov/pubmed/24117347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12378
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