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Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus.

Recent studies have demonstrated that reduced insulin-stimulated muscle glycogen synthesis is the major cause of insulin resistance in patients with non-insulin-dependent diabetes mellitus (NIDDM). This reduced rate has been assigned to a defect in either glucose transport or hexokinase activity. Ho...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rothman, D L, Magnusson, I, Cline, G, Gerard, D, Kahn, C R, Shulman, R G, Shulman, G I
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42621/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7862678/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.4.983
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