Proprotein convertase FURIN constrains Th2 differentiation and is critical for host resistance against Toxoplasma gondii

The proprotein convertase subtilisin/kexin (PCSK) enzymes proteolytically convert immature proproteins into bioactive molecules and thereby they serve as key regulators of cellular homeostasis. The archetype PCSK, FURIN is a direct target gene of the IL-12/STAT4 pathway and it is upregulated in T he...

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Gepubliceerd in:J Immunol
Hoofdauteurs: Oksanen, Anna, Aittomäki, Saara, Jankovic, Dragana, Ortutay, Zsuzsanna, Pulkkinen, Kati, Hämäläinen, Sanna, Rokka, Anne, Corthals, Garry L., Watford, Wendy T., Junttila, Ilkka, O’Shea, John J., Pesu, Marko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261955/
https://ncbi.nlm.nih.gov/pubmed/25355923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401629
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