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Probucol suppresses human glioma cell proliferation in vitro via ROS production and LKB1-AMPK activation

AIM: Probucol, an anti-hyperlipidemic drug, has been reported to exert antitumor activities at various stages of tumor initiation, promotion and progression. In this study we examined whether the drug affected glioma cell growth in vitro and the underlying mechanisms. METHODS: Human glioma U87 and g...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Jiang, Yong-sheng, Lei, Jing-an, Feng, Fang, Liang, Qi-ming, Wang, Fu-rong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261125/
https://ncbi.nlm.nih.gov/pubmed/25399650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.88
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