Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8

The trafficking of AMPA receptors (AMPARs) to and from synapses is crucial for synaptic plasticity. Previous work has demonstrated that AMPARs undergo activity-dependent ubiquitination by the E3 ubiquitin ligase Nedd4-1, which promotes their internalization and degradation in lysosomes. Here, we def...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Scudder, Samantha L., Goo, Marisa S., Cartier, Anna E., Molteni, Alice, Schwarz, Lindsay A., Wright, Rebecca, Patrick, Gentry N.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4261092/
https://ncbi.nlm.nih.gov/pubmed/25505317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2452-14.2014
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