p53-Dependent Activation of microRNA-34a in Response to Etoposide-Induced DNA Damage in Osteosarcoma Cell Lines Not Impaired by Dominant Negative p53 Expression

Osteosarcoma (OS) is the most common primary malignant bone tumor and prevalently occurs in the second decade of life. Etoposide, a chemotherapeutic agent used in combined treatments of recurrent human OS, belongs to the topoisomerase inhibitor family and causes DNA breakage. In this study we evalua...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Novello, Chiara, Pazzaglia, Laura, Conti, Amalia, Quattrini, Irene, Pollino, Serena, Perego, Paola, Picci, Piero, Benassi, Maria Serena
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260944/
https://ncbi.nlm.nih.gov/pubmed/25490093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114757
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