p53-Dependent Activation of microRNA-34a in Response to Etoposide-Induced DNA Damage in Osteosarcoma Cell Lines Not Impaired by Dominant Negative p53 Expression

Osteosarcoma (OS) is the most common primary malignant bone tumor and prevalently occurs in the second decade of life. Etoposide, a chemotherapeutic agent used in combined treatments of recurrent human OS, belongs to the topoisomerase inhibitor family and causes DNA breakage. In this study we evalua...

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Veröffentlicht in:PLoS One
Hauptverfasser: Novello, Chiara, Pazzaglia, Laura, Conti, Amalia, Quattrini, Irene, Pollino, Serena, Perego, Paola, Picci, Piero, Benassi, Maria Serena
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260944/
https://ncbi.nlm.nih.gov/pubmed/25490093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114757
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