Loading of nuclear autoantigens prototypically recognized by systemic lupus erythematosus sera into late apoptotic vesicles requires intact microtubules and myosin light chain kinase activity

Most cases of systemic lupus erythematosus (SLE) are characterized by an impaired clearance of apoptotic cells in various tissues. Non-cleared apoptotic waste is considered an immunogen driving the autoimmune response in patients with SLE. During the execution of apoptosis, membrane blebs are formed...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Clin Exp Immunol
Hlavní autoři: Zirngibl, M, Fürnrohr, B G, Janko, C, Munoz, L E, Voll, R E, Gregory, C D, Schett, G, Herrmann, M
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2015
Témata:
Focus on Dying Autologous Cells as Instructors of the Immune System. Series Originators and Editors: Christian Berens and Martin Herrmann
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260895/
https://ncbi.nlm.nih.gov/pubmed/24673456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12342
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky