Loading of nuclear autoantigens prototypically recognized by systemic lupus erythematosus sera into late apoptotic vesicles requires intact microtubules and myosin light chain kinase activity

Most cases of systemic lupus erythematosus (SLE) are characterized by an impaired clearance of apoptotic cells in various tissues. Non-cleared apoptotic waste is considered an immunogen driving the autoimmune response in patients with SLE. During the execution of apoptosis, membrane blebs are formed...

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Bibliografiske detaljer
Udgivet i:Clin Exp Immunol
Main Authors: Zirngibl, M, Fürnrohr, B G, Janko, C, Munoz, L E, Voll, R E, Gregory, C D, Schett, G, Herrmann, M
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2015
Fag:
Focus on Dying Autologous Cells as Instructors of the Immune System. Series Originators and Editors: Christian Berens and Martin Herrmann
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260895/
https://ncbi.nlm.nih.gov/pubmed/24673456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12342
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