Comparison of Neutralizing Antibody Responses Elicited from Highly Diverse Polyvalent Heterotrimeric HIV-1 gp140 Cocktail Immunogens versus a Monovalent Counterpart in Rhesus Macaques

Eliciting neutralizing antibodies capable of inactivating a broad spectrum of HIV-1 strains is a major goal of HIV-1 vaccine design. The challenge is that envelopes (Envs) of circulating viruses are almost certainly different from any Env used in a vaccine. A novel immunogen composed of a highly div...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bowles, Emma J., Schiffner, Torben, Rosario, Maximillian, Needham, Gemma A., Ramaswamy, Meghna, McGouran, Joanna, Kessler, Benedikt, LaBranche, Celia, McMichael, Andrew J., Montefiori, David, Sattentau, Quentin J., Hanke, Tomáš, Stewart-Jones, Guillaume B. E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260879/
https://ncbi.nlm.nih.gov/pubmed/25490553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114709
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