Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells

Castration-resistant prostate cancer (CRPC) cells acquire resistance to chemotherapy and apoptosis, in part, due to enhanced aerobic glycolysis and biomass production, known as the Warburg effect. We previously demonstrated that combination simvastatin (SIM) and metformin (MET) ameliorates critical...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cell Death Dis
Huvudupphovsmän: Babcook, M A, Sramkoski, R M, Fujioka, H, Daneshgari, F, Almasan, A, Shukla, S, Nanavaty, R R, Gupta, S
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2014
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260755/
https://ncbi.nlm.nih.gov/pubmed/25412314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.500
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk