Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells

Castration-resistant prostate cancer (CRPC) cells acquire resistance to chemotherapy and apoptosis, in part, due to enhanced aerobic glycolysis and biomass production, known as the Warburg effect. We previously demonstrated that combination simvastatin (SIM) and metformin (MET) ameliorates critical...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Babcook, M A, Sramkoski, R M, Fujioka, H, Daneshgari, F, Almasan, A, Shukla, S, Nanavaty, R R, Gupta, S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260755/
https://ncbi.nlm.nih.gov/pubmed/25412314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.500
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