CYTOKINE-INDUCED ALTERATIONS OF α7 NICOTINIC RECEPTOR IN COLONIC CD4 T CELLS MEDIATE DICHOTOMOUS RESPONSE TO NICOTINE IN MURINE MODELS OF Th1/Th17 VS. Th2-MEDIATED COLITIS

Ulcerative colitis (UC) and Crohn’s disease (CD) are two forms of chronic inflammatory bowel disease. CD4 T cells play a central role in the pathogenesis of both diseases. Smoking affects both UC and CD but with opposite effects, ameliorating UC and worsening CD. We hypothesized that the severity of...

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Udgivet i:J Immunol
Main Authors: Galitovskiy, Valentin, Qian, Jing, Chernyavsky, Alexander I., Marchenko, Steve, Gindi, Vivian, Edwards, Robert A., Grando, Sergei A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260719/
https://ncbi.nlm.nih.gov/pubmed/21784975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002711
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