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Reducing the genetic code induces massive rearrangement of the proteome

Expanding the genetic code is an important aim of synthetic biology, but some organisms developed naturally expanded genetic codes long ago over the course of evolution. Less than 1% of all sequenced genomes encode an operon that reassigns the stop codon UAG to pyrrolysine (Pyl), a genetic code vari...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: O’Donoghue, Patrick, Prat, Laure, Kucklick, Martin, Schäfer, Johannes G., Riedel, Katharina, Rinehart, Jesse, Söll, Dieter, Heinemann, Ilka U.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260545/
https://ncbi.nlm.nih.gov/pubmed/25404328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1420193111
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