A Corin Variant Identified in Hypertensive Patients That Alters Cytoplasmic Tail and Reduces Cell Surface Expression and Activity

Corin is a membrane-bound protease that regulates blood pressure by activating the natriuretic peptides. CORIN variants have been associated with hypertension and heart disease in African Americans. In this study, we conducted targeted exome sequencing and identified an insertion variant, c.102_103i...

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Publicado no:Sci Rep
Main Authors: Zhang, Yue, Li, Hui, Zhou, Jianping, Wang, Aili, Yang, Junhua, Wang, Can, Liu, Meng, Zhou, Tiantian, Zhu, Li, Zhang, Yonghong, Dong, Ningzheng, Wu, Qingyu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260221/
https://ncbi.nlm.nih.gov/pubmed/25488193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07378
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