Differential proteomic profiling unveils new molecular mechanisms associated with mitochondrial complex III deficiency

We have analyzed the cellular pathways and metabolic adaptations that take place in primary skin fibroblasts from patients with mutations in BCS1L, a major genetic cause of mitochondrial complex III enzyme deficiency. Mutant fibroblasts exhibited low oxygen consumption rates and intracellular ATP le...

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Veröffentlicht in:J Proteomics
Hauptverfasser: Marín-Buera, Lorena, García-Bartolomé, Alberto, Morán, María, López-Bernardo, Elia, Cadenas, Susana, Hidalgo, Beatriz, Sánchez, Ricardo, Seneca, Sara, Arenas, Joaquín, Martín, Miguel A., Ugalde, Cristina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259860/
https://ncbi.nlm.nih.gov/pubmed/25239759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2014.09.007
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