Leptin Mediates the Increase in Blood Pressure Associated with Obesity

Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or lep...

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Pubblicato in:Cell
Autori principali: Simonds, Stephanie E., Pryor, Jack T., Ravussin, Eric, Greenway, Frank L., Dileone, Ralph, Allen, Andrew M., Bassi, Jaspreet, Elmquist, Joel K., Keogh, Julia M., Henning, Elana, Myers, Martin G., Licinio, Julio, Brown, Russell D., Enriori, Pablo J., O’Rahilly, Stephen, Sternson, Scott M., Grove, Kevin L., Spanswick, David C., Farooqi, I. Sadaf, Cowley, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259491/
https://ncbi.nlm.nih.gov/pubmed/25480301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.10.058
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