Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences

Mutational profiling of triple-negative breast cancer (TNBC) by whole exome sequencing (WES) yielded a landscape of genomic alterations in this tumor entity. However, the clinical significance of these findings remains enigmatic. Further, integration of WES in routine diagnostics using formalin-fixe...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Kriegsmann, Mark, Endris, Volker, Wolf, Thomas, Pfarr, Nicole, Stenzinger, Albrecht, Loibl, Sibylle, Denkert, Carsten, Schneeweiss, Andreas, Budczies, Jan, Sinn, Peter, Weichert, Wilko
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2014
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259450/
https://ncbi.nlm.nih.gov/pubmed/25296970
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