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Vertebrate Hedgehog is secreted on two types of extracellular vesicles with different signaling properties

Hedgehog (Hh) is a secreted morphogen that elicits differentiation and patterning in developing tissues. Multiple proposed mechanisms to regulate Hh dispersion includes lipoprotein particles and exosomes. Here we report that vertebrate Sonic Hedgehog (Shh) is secreted on two types of extracellular-v...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vyas, Neha, Walvekar, Ankita, Tate, Dhananjay, Lakshmanan, Vairavan, Bansal, Dhiru, Cicero, Alessandra Lo, Raposo, Graca, Palakodeti, Dasaradhi, Dhawan, Jyotsna
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258658/
https://ncbi.nlm.nih.gov/pubmed/25483805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07357
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