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Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

We compared mouse embryonic stem (ES) cells and fibroblasts (MEFs) for their ability to metabolically activate the environmental carcinogens benzo[a]pyrene (BaP), 3-nitrobenzanthrone (3-NBA) and aristolochic acid I (AAI), measuring DNA adduct formation by (32)P-postlabelling and expression of xenobi...

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Bibliografiske detaljer
Udgivet i:Toxicol In Vitro
Main Authors: Krais, Annette M., Mühlbauer, Karl-Rudolf, Kucab, Jill E., Chinbuah, Helena, Cornelius, Michael G., Wei, Quan-Xiang, Hollstein, Monica, Phillips, David H., Arlt, Volker M., Schmeiser, Heinz H.
Format: Artigo
Sprog:Inglês
Udgivet: Pergamon Press 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258613/
https://ncbi.nlm.nih.gov/pubmed/25230394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2014.09.004
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