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Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene
To date, there has been no way to examine induced human p53 gene mutations in cell cultures exposed to mutagenic factors, other than by restriction site analysis. Here, we used embryonic cells from our Hupki (human p53 knock-in) mouse strain to generate human p53 DNA-binding domain (DBD) mutations e...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC365728/ https://ncbi.nlm.nih.gov/pubmed/14976251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308607101 |
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