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Mechanism of oxidative inactivation of human presequence protease (hPreP) by hydrogen peroxide
The mitochondrial presequence protease (PreP) is a member of the pitrilysin class of metalloproteases. It degrades the mitochondrial targeting presequences of mitochondria-localized proteins as well as unstructured peptides such as amyloid-β-peptide. The specific activity of PreP is reduced in Alzhe...
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| Izdano u: | Free Radic Biol Med |
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| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258540/ https://ncbi.nlm.nih.gov/pubmed/25236746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.08.016 |
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