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Blockade of mTOR Signaling via Rapamycin Combined with Immunotherapy Augments Anti-glioma Cytotoxic and Memory T cells’ Functions

The success of immunotherapeutic approaches targeting Glioblastomamultiforme demand a robust anti-glioma T cell cytotoxic and memory response. Recent evidence suggests that Rapamycin regulates T cell differentiation. Herein, we tested whether administration of Rapamycin could enhance the efficacy of...

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Publicat a:Mol Cancer Ther
Autors principals: Mineharu, Yohei, Kamran, Neha, Lowenstein, Pedro R, Castro, Maria G
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258521/
https://ncbi.nlm.nih.gov/pubmed/25256739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0400
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