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TRAM is required for TLR2 endosomal signaling to type I IFN induction
Detection of microbes by TLRs on the plasma membrane leads to the induction of pro-inflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively, activation of endosomal TLRs leads to the induction of type I IFNs via IFN regulatory factors (IRFs). TLR4 signaling from the plasma membra...
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| Опубликовано в: : | J Immunol |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258402/ https://ncbi.nlm.nih.gov/pubmed/25385819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401605 |
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