TRAM is required for TLR2 endosomal signaling to type I IFN induction

Detection of microbes by TLRs on the plasma membrane leads to the induction of pro-inflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively, activation of endosomal TLRs leads to the induction of type I IFNs via IFN regulatory factors (IRFs). TLR4 signaling from the plasma membra...

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Publicado en:J Immunol
Autores principales: Stack, Julianne, Doyle, Sarah L., Connolly, Dympna J., Reinert, Line S., O’Keeffe, Kate M., McLoughlin, Rachel M., Paludan, Søren R., Bowie, Andrew G.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258402/
https://ncbi.nlm.nih.gov/pubmed/25385819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401605
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