Wird geladen...
TRAM is required for TLR2 endosomal signaling to type I IFN induction
Detection of microbes by TLRs on the plasma membrane leads to the induction of pro-inflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively, activation of endosomal TLRs leads to the induction of type I IFNs via IFN regulatory factors (IRFs). TLR4 signaling from the plasma membra...
Gespeichert in:
| Veröffentlicht in: | J Immunol |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4258402/ https://ncbi.nlm.nih.gov/pubmed/25385819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401605 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|