CONSERVED HIGHER ORDER CHROMATIN REGULATES NMDA RECEPTOR GENE EXPRESSION AND COGNITION

3-dimensional chromosomal conformations regulate transcription by moving enhancers and regulatory elements into spatial proximity with target genes. Here, we describe activity-regulated long-range loopings bypassing up to 0.5 megabase of linear genome to modulate NMDA glutamate receptor GRIN2B expre...

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Publicat a:Neuron
Autors principals: Bharadwaj, Rahul, Peter, Cyril J., Jiang, Yan, Roussos, Panos, Vogel-Ciernia, Annie, Shen, Erica, Mitchell, Amanda, Mao, Wenjie, Whittle, Catheryne, Dincer, Aslihan, Jakovcevski, Mira, Pothula, Venu, Rasmussen, Theodore P., Giakoumaki, Stella G., Bitsios, Panos, Sherif, Ajfar, Gardner, Paul D., Ernst, Patricia, Ghose, Subroto, Sklar, Pamela, Haroutunian, Vahram, Tamminga, Carol, Myers, Richard H., Futai, Kensuke, Wood, Marcelo A., Akbarian, Schahram
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258154/
https://ncbi.nlm.nih.gov/pubmed/25467983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.10.032
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