CONSERVED HIGHER ORDER CHROMATIN REGULATES NMDA RECEPTOR GENE EXPRESSION AND COGNITION

3-dimensional chromosomal conformations regulate transcription by moving enhancers and regulatory elements into spatial proximity with target genes. Here, we describe activity-regulated long-range loopings bypassing up to 0.5 megabase of linear genome to modulate NMDA glutamate receptor GRIN2B expre...

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Publicado en:Neuron
Main Authors: Bharadwaj, Rahul, Peter, Cyril J., Jiang, Yan, Roussos, Panos, Vogel-Ciernia, Annie, Shen, Erica, Mitchell, Amanda, Mao, Wenjie, Whittle, Catheryne, Dincer, Aslihan, Jakovcevski, Mira, Pothula, Venu, Rasmussen, Theodore P., Giakoumaki, Stella G., Bitsios, Panos, Sherif, Ajfar, Gardner, Paul D., Ernst, Patricia, Ghose, Subroto, Sklar, Pamela, Haroutunian, Vahram, Tamminga, Carol, Myers, Richard H., Futai, Kensuke, Wood, Marcelo A., Akbarian, Schahram
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258154/
https://ncbi.nlm.nih.gov/pubmed/25467983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.10.032
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