An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease

Peripheral artery disease (PAD) generates tissue ischemia through arterial occlusions and insufficient collateral vessel formation. Vascular insufficiency in PAD occurs despite higher circulating levels of vascular endothelial growth factor A (VEGF-A),(1,2) a key regulator of angiogenesis. Here, we...

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Publicado en:Nat Med
Autores principales: Kikuchi, Ryosuke, Nakamura, Kazuto, MacLauchlan, Susan, Ngo, Doan Thi-Minh, Shimizu, Ippei, Fuster, Jose Javier, Katanasaka, Yasufumi, Yoshida, Sumiko, Qiu, Yan, Yamaguchi, Terry P., Matsushita, Tadashi, Murohara, Toyoaki, Gokce, Noyan, Bates, David O., Hamburg, Naomi M., Walsh, Kenneth
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257756/
https://ncbi.nlm.nih.gov/pubmed/25362254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3703
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