Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants.

A nontoxic mutant (LTK7) of the Escherichia coli heat-labile enterotoxin (LT) lacking ADP-ribosylating activity but retaining holotoxin formation was constructed. By using site-directed mutagenesis, the arginine at position 7 of the A subunit was replaced with lysine. This molecule, which was nontox...

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出版年:	Proc Natl Acad Sci U S A
主要な著者:	Douce, G, Turcotte, C, Cropley, I, Roberts, M, Pizza, M, Domenghini, M, Rappuoli, R, Dougan, G
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 1995
主題:	Research Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7878032/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.5.1644
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