Insight into the Effect of Inhibitor Resistant S130G Mutant on Physico-Chemical Properties of SHV Type Beta-Lactamase: A Molecular Dynamics Study

Bacterial resistance is a serious threat to human health. The production of β-lactamase, which inactivates β-lactams is most common cause of resistance to the β-lactam antibiotics. The Class A enzymes are most frequently encountered among the four β-lactamases in the clinic isolates. Mutations in cl...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Baig, Mohd Hassan, Sudhakar, D. Raja, Kalaiarasan, Ponnusamy, Subbarao, Naidu, Wadhawa, Gulshan, Lohani, Mohtashim, Khan, M Kalim A, Khan, Asad U.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257546/
https://ncbi.nlm.nih.gov/pubmed/25479359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112456
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