Triptolide treatment reduces Alzheimer’s disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD

The complex pathogenesis of Alzheimer’s disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic strategies for AD are still urgently needed. Triptolide is the major active compound extracted from Tri...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Wang, Qi, Xiao, Bing, Cui, Shuqin, Song, Hailong, Qian, Yanjing, Dong, Lin, An, Haiting, Cui, Yanqiu, Zhang, Wenjing, He, Yi, Zhang, Jianliang, Yang, Jian, Zhang, Feilong, Hu, Guanzheng, Gong, Xiaoli, Yan, Zhen, Zheng, Yan, Wang, Xiaomin
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4257007/
https://ncbi.nlm.nih.gov/pubmed/25481013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018218
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