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A Novel and Fast Approach for Population Structure Inference Using Kernel-PCA and Optimization

Population structure is a confounding factor in genome-wide association studies, increasing the rate of false positive associations. To correct for it, several model-based algorithms such as ADMIXTURE and STRUCTURE have been proposed. These tend to suffer from the fact that they have a considerable...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Popescu, Andrei-Alin, Harper, Andrea L., Trick, Martin, Bancroft, Ian, Huber, Katharina T.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256762/
https://ncbi.nlm.nih.gov/pubmed/25326237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.171314
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