The Functional Landscape of Hsp27 Reveals New Cellular Processes such as DNA Repair and Alternative Splicing and Proposes Novel Anticancer Targets

Previously, we identified the stress-induced chaperone, Hsp27, as highly overexpressed in castration-resistant prostate cancer and developed an Hsp27 inhibitor (OGX-427) currently tested in phase I/II clinical trials as a chemosensitizing agent in different cancers. To better understand the Hsp27 po...

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Detalhes bibliográficos
Publicado no:Mol Cell Proteomics
Main Authors: Katsogiannou, Maria, Andrieu, Claudia, Baylot, Virginie, Baudot, Anaïs, Dusetti, Nelson J., Gayet, Odile, Finetti, Pascal, Garrido, Carmen, Birnbaum, Daniel, Bertucci, François, Brun, Christine, Rocchi, Palma
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256507/
https://ncbi.nlm.nih.gov/pubmed/25277244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.041228
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