Mediation Analysis Demonstrates That Trans-eQTLs Are Often Explained by Cis-Mediation: A Genome-Wide Analysis among 1,800 South Asians

A large fraction of human genes are regulated by genetic variation near the transcribed sequence (cis-eQTL, expression quantitative trait locus), and many cis-eQTLs have implications for human disease. Less is known regarding the effects of genetic variation on expression of distant genes (trans-eQT...

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Sparad:
Bibliografiska uppgifter
I publikationen:PLoS Genet
Huvudupphovsmän: Pierce, Brandon L., Tong, Lin, Chen, Lin S., Rahaman, Ronald, Argos, Maria, Jasmine, Farzana, Roy, Shantanu, Paul-Brutus, Rachelle, Westra, Harm-Jan, Franke, Lude, Esko, Tonu, Zaman, Rakibuz, Islam, Tariqul, Rahman, Mahfuzar, Baron, John A., Kibriya, Muhammad G., Ahsan, Habibul
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256471/
https://ncbi.nlm.nih.gov/pubmed/25474530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004818
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