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Selenoprotein H Suppresses Cellular Senescence through Genome Maintenance and Redox Regulation

Oxidative stress and persistent DNA damage response contribute to cellular senescence, a degeneration process critically involving ataxia telangiectasia-mutated (ATM) and p53. Selenoprotein H (SelH), a nuclear selenoprotein, is proposed to carry redox and transactivation domains. To determine the ro...

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Bibliografski detalji
Izdano u:J Biol Chem
Glavni autori: Wu, Ryan T. Y., Cao, Lei, Chen, Benjamin P. C., Cheng, Wen-Hsing
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256366/
https://ncbi.nlm.nih.gov/pubmed/25336634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611970
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