Profound Activity of the Anti-cancer Drug Bortezomib against Echinococcus multilocularis Metacestodes Identifies the Proteasome as a Novel Drug Target for Cestodes

A library of 426 FDA-approved drugs was screened for in vitro activity against E. multilocularis metacestodes employing the phosphoglucose isomerase (PGI) assay. Initial screening at 20 µM revealed that 7 drugs induced considerable metacestode damage, and further dose-response studies revealed that...

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Publicado en:PLoS Negl Trop Dis
Autores principales: Stadelmann, Britta, Aeschbacher, Denise, Huber, Cristina, Spiliotis, Markus, Müller, Joachim, Hemphill, Andrew
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256282/
https://ncbi.nlm.nih.gov/pubmed/25474446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0003352
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