Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegans

In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that the nuclear hormone receptor, NHR-49, enables the response to this physiological change by increasing the expression of genes involved in mitochondrial β-oxidation and fatty-acid desaturation. The coordinated...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Ratnappan, Ramesh, Amrit, Francis R. G., Chen, Shaw-Wen, Gill, Hasreet, Holden, Kyle, Ward, Jordan, Yamamoto, Keith R., Olsen, Carissa P., Ghazi, Arjumand
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4256272/
https://ncbi.nlm.nih.gov/pubmed/25474470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004829
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