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Aip1 destabilizes cofilin-saturated actin filaments by severing and accelerating monomer dissociation from ends
BACKGROUND: Depolymerization of actin filaments is vital for the morphogenesis of dynamic cytoskeletal arrays and actin-dependent cell-motility. Cofilin is necessary for actin disassembly in cells, and it severs filaments most efficiently at low cofilin to actin ratios, whereas higher concentrations...
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| Published in: | Curr Biol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4256095/ https://ncbi.nlm.nih.gov/pubmed/25448002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.09.048 |
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