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Direct analysis of mAb aggregates in mammalian cell culture supernatant
BACKGROUND: Protein aggregation during monoclonal antibody (mAb) production can occur in upstream and downstream processing (DSP). Current methods to determine aggregate formation during cell culture include size exclusion chromatography (SEC) with a previous affinity chromatography step in order to...
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| Published in: | BMC Biotechnol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4256052/ https://ncbi.nlm.nih.gov/pubmed/25431119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-014-0099-3 |
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