Sulindac derivatives inhibit cell growth and induce apoptosis in primary cells from malignant peripheral nerve sheath tumors of NF1-patients

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are neoplasms leading to death in most cases. Patients with Neurofibromatosis type 1 have an increased risk of developing this malignancy. The metabolites of the inactive prodrug Sulindac, Sulindac Sulfide and Sulindac Sulfone (Exisulind)...

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Hauptverfasser: Frahm, Silke, Kurtz, Andreas, Kluwe, Lan, Farassati, Faris, Friedrich, Reinhard E, Mautner, Victor F
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2004
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Primary Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC425591/
https://ncbi.nlm.nih.gov/pubmed/15147581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-4-4
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