MCP‐1 downregulates MMP‐9 export via vesicular redistribution to lysosomes in rat portal fibroblasts

Portal fibroblasts (PF) are one of the two primary cell types contributing to the myofibroblast population of the liver and are thus essential to the pathogenesis of liver fibrosis. Monocyte chemoattractant protein‐1 (MCP‐1) is a known profibrogenic chemokine that may be of particular importance in...

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Udgivet i:Physiol Rep
Main Authors: Hickman, DaShawn A., Syal, Gaurav, Fausther, Michel, Lavoie, Elise G., Goree, Jessica R., Storrie, Brian, Dranoff, Jonathan A.
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Periodicals, Inc. 2014
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255798/
https://ncbi.nlm.nih.gov/pubmed/25413315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.12153
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