Triptolide reverses hypoxia-induced epithelial–mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies characterized by an intense tumor stroma with hypoperfused regions, a significant inflammatory response and pronounced therapy resistance. New therapeutic agents are urgently needed. The plant-derived agent triptolide also...

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Detalles Bibliográficos
Publicado en:Int J Cancer
Autores principales: Liu, Li, Salnikov, Alexei V, Bauer, Nathalie, Aleksandrowicz, Ewa, Labsch, Sabrina, Nwaeburu, Clifford, Mattern, Jürgen, Gladkich, Jury, Schemmer, Peter, Werner, Jens, Herr, Ingrid
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
Materias:
Cancer Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255690/
https://ncbi.nlm.nih.gov/pubmed/24615157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28583
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