Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de novo, enhances migration of existing CSCs or both is unclear. We examined patient tissue of pancreatic ductal adenocarcinoma...

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Hoofdauteurs: Salnikov, Alexei V., Liu, Li, Platen, Mitja, Gladkich, Jury, Salnikova, Olga, Ryschich, Eduard, Mattern, Jürgen, Moldenhauer, Gerhard, Werner, Jens, Schemmer, Peter, Büchler, Markus W., Herr, Ingrid
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458836/
https://ncbi.nlm.nih.gov/pubmed/23050024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046391
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