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Fiber-Dependent and -Independent Toxicity of Islet Amyloid Polypeptide
The 37-residue peptide hormone islet amyloid polypeptide (IAPP) plays a central role in diabetes pathology. Although its amyloid fiber aggregation kinetics and cytotoxicity to β-cells are well documented, few reports have directly assessed the role of fibers in cell-based toxicity experiments. Here,...
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| Publicado no: | Biophys J |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4255681/ https://ncbi.nlm.nih.gov/pubmed/25468335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.09.047 |
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