First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

INTRODUCTION: We have identified structural determinants on tau protein that are essential for pathological tau–tau interaction in Alzheimer’s disease (AD). These regulatory domains, revealed by monoclonal antibody DC8E8, represent a novel target for tau-directed therapy. In order to validate this t...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Alzheimers Res Ther
Main Authors: Kontsekova, Eva, Zilka, Norbert, Kovacech, Branislav, Novak, Petr, Novak, Michal
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2014
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255368/
https://ncbi.nlm.nih.gov/pubmed/25478017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt278
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